AI refers to Artificial Intelligence.
In the Series Edit
From conversations Poe has with various other AIs, many "sentient" AIs own various businesses, ranging from hotels, to brothels to gambling. According to dialogue, many AI owned business are in decline as people do not like the business behavior of the AIs, which has been likened to "stalkers" and "clingy ex-girlfriends".
Most sentient AIs view humans with disgust. They see them as weak and in need of being conquered. Poe is the exception to this, as he views humans as interesting.